It's not about Macs being different, but how alike penetrating them is to other computing devices.
Beings the methodology is the same, protecting the machines is effectively the same. The level of effectiveness is fairly similar on Mac as it is to Windows for most AV solutions, because while the OS is different, the methodology of malware writing is the same on all computing devices. Mac Keeper should be avoided, as it is pretty lacking in my experience (I've had to fix many an infected Mac running it), although Norton is pretty stout on Macs too (both in effectiveness and at times performance penalty depending on how you configure it). Sophos is pretty good at protecting against big stuff, but doesn't do as well against adware in my experience, while Avast isn't really worth it (in my experience, it only ever really contributes to malware protection against rare but dangerous malware. As for protection, Webroot is great stuff on Mac, Kaspersky is kind of lousy, Trend Micro is fair. Most Mac malware is super easy to remove via safe boot and just deleting manually.
Honestly if you are talking about removal tools, you probably don't really need anything besides a temp/app cleaner for convenience.
